La biología detrás de la luz. Y de lo que le hacemos a ella.

"Wearing amber vs. clear lenses for 2 h preceding bedtime for 1 week improved sleep in individuals with insomnia symptoms. Amber lenses represent a safe, affordable, and easily implemented therapeutic intervention."

"BB glasses may be useful in adolescents as a countermeasure for alerting effects induced by light exposure through LED screens and therefore potentially impede the negative effects modern lighting imposes on circadian physiology in the evening."

"Overnight melatonin secretion was significantly higher after using the blue-light shield. Sleep efficacy and sleep latency were significantly superior for wearers of the blue-light shield."

"A significant reduction of melatonin was observed with the grey lens. Blue-blocking glasses impede bright light's capacity to suppress melatonin."

"All light is not equal: blue wavelengths are the most potent portion of the visible electromagnetic spectrum for circadian regulation. Blocking blue light could create a form of physiologic darkness."

"Global PSQI scores fell from 11.15 to 4.54, dropping below the cut-off score of 5 for clinical insomnia. The more phase-delayed subjects trended towards an earlier midsleep time by 43.2 minutes."

"The circadian clock is most sensitive to the blue portion of the visible spectrum. Blocking short wavelengths below 540 nm could improve daytime sleep quality and nighttime vigilance of night shiftworkers."

"Those with the 'real glasses' recovered somewhat more quickly than those with the placebo glasses. Exposing the eyes to light in the blue end of the visible spectrum suppresses the production of melatonin."

"Amber-tinted safety glasses have already been shown to preserve normal nocturnal melatonin levels in a light environment which otherwise completely suppresses melatonin production."

"The mean decline in YMRS score was 14.1 in the BB group, and 1.7 in the placebo group, yielding an effect size of 1.86 (Cohen's d). BB glasses are effective and feasible as add-on treatment for bipolar mania."

"Most clinical studies comparing IOLs with and without the blue light-filtering feature have found no difference in clinical performance for visual acuity, contrast sensitivity, color vision, or glare."

"446–477 nm is the most potent wavelength region providing circadian input for regulating melatonin secretion. A single photopigment may be primarily responsible for melatonin suppression, distinct from rod and cone photopigments."

"Nonvisual responses — including effects on the circadian system, melatonin secretion, sleep/alertness — originate via intrinsically photosensitive retinal ganglion cells (ipRGCs)."

"Short-wavelength illumination significantly disrupted sleep continuity and architecture and led to greater self-reported daytime sleepiness. It also altered biological rhythms, subduing the normal nocturnal decline in body temperature."

"Light at night suppresses melatonin production, which alters circadian entrainment and leads to sleep deprivation with multiple health consequences including increased risks for depression, metabolic disorders, and cancer."

"Blue light, relative to green light, increased brain responses primarily in the ventrolateral and dorsolateral prefrontal cortex. Light acts as an activating agent particularly under adverse circadian phase and high homeostatic sleep pressure."

"Electrical lighting is associated with reduced sunlight exposure during the day, increased light after sunset, and a delayed timing of the circadian clock — contributing to late sleep schedules and disrupted circadian rhythms."

"Light operating through the circadian system is known to influence sleep patterns and believed to be linked to the development of breast cancer among night shift workers."

"ALAN is a growing, major concern for human health through disruption of the production of melatonin; changes to melatonin alter circadian entrainment, leading to increased cancer risks, altered sleep and cognitive problems."

"Blue light increased activity in the left middle frontal gyrus, left thalamus and bilateral brainstem consistent with activation of the locus coeruleus. Results support a prominent contribution of melanopsin-expressing retinal ganglion cells."

"The same blue light that has the strongest impact on early photosynthetic organisms has equal power to reset our own clocks. Desynchronization of circadian rhythms may play a role in tumoral diseases, diabetes, obesity, and depression."

"Short-wave blue light between 415–455 nm is closely related to eye light damage. This high energy blue light passes through the cornea and lens to the retina causing diseases such as dry eye, cataract, age-related macular degeneration."

"LED light caused oxidative damage and retinal injury. We observed a loss of photoreceptors and the activation of caspase-independent apoptosis, necroptosis, and necrosis."

"The most harmful component of visible light is the blue wavelength (400–500 nm). A filter that removes 94% of the blue component may protect the function and morphology of the retina significantly."

"Overexposure to blue light with short wavelengths can induce oxidative damage and apoptosis to the cornea, which may manifest as increased ocular surface inflammation and resultant dry eye."

"Oxidative stress initiated in an individual cell by photostimulation (488 nm) triggered changes in reactive oxygen species (ROS), Ca2+ and mitochondrial membrane potential."

"Daily exposure of differentiated adipocytes to blue light resulted in decreased lipid droplet size, increased basal lipolytic rate and alterations in adiponectin and leptin secretion."

"The blue region (400–500 nm) has relatively high energy and can penetrate tissue. Irradiation of mammalian cells with visible light induces cellular damage primarily via reactive oxygen species (ROS)."